Cops say Rendon had a violent history with women when he snapped and allegedly killed his 16-year-old girlfriend.
Police say Rendon could be traveling throughout Texas and Mexico. Call our Hotline right away at 1-800-CRIME-TV if you've seen him.
Authorities say the hotel staff of the Coach Light Inn was notified by a keen-eyed guest after seeing blood outside Room 220.
Cops arrived at the Coach Light Inn in Amarillo, Texas, to find a grisly murder had gone down in a second-floor hotel room.
Have you seen accused murderer Carlos Daniel Rendon?
If so, be very careful, but don't be afraid to call our Hotline at 1-800-CRIME-TV.
You can remain anonymous.
Jessica Sills, 16, was reported as a runaway just one month before Carlos Rendon allegedly beat and strangled her to death, leaving her for dead in a seedy Amarillo, Texas, motel room.
Cops tell AMW that Rendon -- now 32 years old -- prefers to be clean shaven and usually keeps his hair closely cropped.